To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00748
Peptide Name IIW
Sequence IEEIWKKIEEIWKKIEEIWKKIEEIWKKIEEIWKKXX
Sequence Length 37
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism MERS-CoV
Assay MERS-CoV S Protein-Mediated Cell–Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide can interact with both MERS-CoV and IAV NHR trimeric coiled coils to prevent virus–cell membrane fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid).
Stereochemistry L
Physicochemical Information
Formula C225H348N50O54
Absent amino acids ACDFGHLMNPQRSTVY
Common amino acids EIK
Mass 4876.23
Pl 6.49
Basic residues 10
Acidic residues 10
Hydrophobic residues 15
Net charge 0
Boman Index -6275
Hydrophobicity -90.54
Aliphatic Index 105.41
Half Life
Extinction Coefficient cystines 27500
Absorbance 280nm 763.89
Polar residues 0
Literature Information
Literature 1
Title De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery.
Pubmed ID 30192544
Reference J Med Chem. 2018 Oct 11;61(19):8734-8745.
Author Wang C, Zhao L, Xia S, Zhang T, Cao R, Liang G, Li Y, Meng G, Wang W, Shi W, Zhong W, Jiang S, Liu K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.