General Information

General Information

DRAVP ID DRAVPe00754

Peptide Name Eval418-FH2

Sequence LWGHIWNFVHGLI

Sequence Length 13

UniProt ID No entry found

Source Synthetic construct(derived from Eval418)

Activity Information

Target Organism HSV

Assay Antiviral assays

Activity

[Ref.29290802]HSV-1:inhibition of viral inactivation in Vero cells(IC50=1.50 μg/ml);inhibition of viral attachment in Vero cells(IC50=1.43 μg/ml);inhibition of viral entry in Vero cells(IC50=8.63 μg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.29290802]Vero cell:CC50=27.60 μg/mL.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00754

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C80H110N20O15

Absent amino acids ACDEKMPQRSTY

Common amino acids GHILW

Mass 1591.88

Pl 6.92

Basic residues 2

Acidic residues 0

Hydrophobic residues 8

Net charge 2

Boman Index 1728

Hydrophobicity 85.38

Aliphatic Index 142.31

Half Life

Mammalian:5.5 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 11000

Absorbance 280nm 916.67

Polar residues 3

Literature Information

Literature 1

Title Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID 29290802

Reference Theranostics. 2018 Jan 1;8(1):199-211.

Author Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI 10.7150/thno.21425