General Information

General Information

DRAVP ID DRAVPe00754

Peptide Name Eval418-FH2

Sequence LWGHIWNFVHGLI

Sequence Length 13

UniProt ID No entry found

Taxon ID None

Source Synthetic construct(derived from Eval418)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HSV

Assay Antiviral assays

Activity

[Ref.29290802]HSV-1:inhibition of viral inactivation in Vero cells(IC50=1.50 μg/ml);inhibition of viral attachment in Vero cells(IC50=1.43 μg/ml);inhibition of viral entry in Vero cells(IC50=8.63 μg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.29290802]Vero cell:CC50=27.60 μg/mL.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00754

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C80H110N20O15

Absent amino acids ACDEKMPQRSTY

Common amino acids GHILW

Mass 1591.88

Pl 6.92

Basic residues 2

Acidic residues 0

Hydrophobic residues 8

Net charge 2

Boman Index 1728

Hydrophobicity 85.38

Aliphatic Index 142.31

Half Life

Mammalian:5.5 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 11000

Absorbance 280nm 916.67

Polar residues 3

Literature Information

Literature 1

Title Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID 29290802

Reference Theranostics. 2018 Jan 1;8(1):199-211.

Author Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI 10.7150/thno.21425