DRAVP ID  DRAVPe00763

Peptide Name   Alloferon (4-13)

Sequence  SGHGQHGVHG

Sequence Length  10

UniProt ID  P83412 

Source  Synthetic construct(derived from Alloferon-1)

Target Organism  Herpesvirus,Coxsackie virus

Assay  antiviral assay

Activity 

• [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=186 µM);inhibition of virus replication in Hep-2 cells(IC50=310 µM);
• HHV-1 clinical strain:inhibition of virus replication in Vero cells(IC50=173 µM);inhibition of virus replication in Hep-2 cells(IC50=450 µM);
• Coxsackie virus B2(clinical strain):inhibition of virus replication in Hep-2 cells(IC50=170 µM);inhibition of virus replication in LLC-MK2 cells(IC50=170 µM);
• Coxsackie virus 971 PT B2:inhibition of virus replication in HEp-2 cells(IC50=210 µM);inhibition of virus replication in LLC-MK2 cells(IC50=180 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 420 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  DRAVPe00763

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   New alloferon analogues: synthesis and antiviral properties.

Pubmed ID   22883213

Reference   Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author   Kuczer M, Majewska A, Zahorska R.

DOI   10.1111/cbdd.12020