General Information


DRAVP ID  DRAVPe00764

Peptide Name   Alloferon (5-13)

Sequence  GHGQHGVHG

Sequence Length  9

UniProt ID  P83412 

Source  Synthetic construct(derived from Alloferon-1)



Activity Information


Target Organism  Herpesvirus,Coxsackie virus

Assay  antiviral assay

Activity 

  • [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Hep-2 cells(IC50=360 µM);
  • HHV-1 clinical strain:inhibition of virus replication in Hep-2 cells(IC50=290 µM);
  • Coxsackie virus B2(clinical strain):inhibition of virus replication in Hep-2 cells(IC50=170 µM);
  • Coxsackie virus 971 PT B2:inhibition of virus replication in LLC-MK2 cells(IC50=230 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 448 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00764

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C36H52N16O11

Absent amino acids  ACDEFIKLMNPRSTWY

Common amino acids  G

Mass  884.91

Pl  7.02

Basic residues  3

Acidic residues  0

Hydrophobic residues  1

Net charge  3

Boman Index  -1172

Hydrophobicity  -116.67

Aliphatic Index  32.22

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4



Literature Information


Literature 1

Title   New alloferon analogues: synthesis and antiviral properties.

Pubmed ID   22883213

Reference   Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author   Kuczer M, Majewska A, Zahorska R.

DOI   10.1111/cbdd.12020