DRAVP ID  DRAVPe00765

Peptide Name   Alloferon (6-13)

Sequence  HGQHGVHG

Sequence Length  8

UniProt ID  P83412 

Taxon ID  None

Source  Synthetic construct(derived from Alloferon-1)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  Herpesvirus,Coxsackie virus

Assay  antiviral assay

Activity 

• [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=179 µM);
• HHV-1 clinical strain:inhibition of virus replication in Vero cells(IC50=117 µM);
• Coxsackie virus B2(clinical strain):inhibition of virus replication in Hep-2 cells(IC50=78 µM);inhibition of virus replication in LLC-MK2 cells(IC50=170 µM);
• Coxsackie virus 971 PT B2:inhibition of virus replication in HEp-2 cells(IC50=190 µM);inhibition of virus replication in LLC-MK2 cells(IC50=410 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 468 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  DRAVPe00765

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   New alloferon analogues: synthesis and antiviral properties.

Pubmed ID   22883213

Reference   Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author   Kuczer M, Majewska A, Zahorska R.

DOI   10.1111/cbdd.12020