General Information

General Information

DRAVP ID DRAVPe00765

Peptide Name Alloferon (6-13)

Sequence HGQHGVHG

Sequence Length 8

UniProt ID P83412

Source Synthetic construct(derived from Alloferon-1)

Activity Information

Target Organism Herpesvirus,Coxsackie virus

Assay antiviral assay

Activity

[Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=179 µM);
HHV-1 clinical strain:inhibition of virus replication in Vero cells(IC50=117 µM);
Coxsackie virus B2(clinical strain):inhibition of virus replication in Hep-2 cells(IC50=78 µM);inhibition of virus replication in LLC-MK2 cells(IC50=170 µM);
Coxsackie virus 971 PT B2:inhibition of virus replication in HEp-2 cells(IC50=190 µM);inhibition of virus replication in LLC-MK2 cells(IC50=410 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 468 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00765

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C34H49N15O10

Absent amino acids ACDEFIKLMNPRSTWY

Common amino acids GH

Mass 827.86

Pl 7.02

Basic residues 3

Acidic residues 0

Hydrophobic residues 1

Net charge 3

Boman Index -1266

Hydrophobicity -126.25

Aliphatic Index 36.25

Half Life

Mammalian:3.5 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Literature Information

Literature 1

Title New alloferon analogues: synthesis and antiviral properties.

Pubmed ID 22883213

Reference Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author Kuczer M, Majewska A, Zahorska R.

DOI 10.1111/cbdd.12020