General Information

General Information

DRAVP ID DRAVPe00769

Peptide Name Alloferon (10-13)

Sequence GVHG

Sequence Length 4

UniProt ID P83412

Source Synthetic construct(derived from Alloferon-1)

Activity Information

Target Organism Herpesvirus,Coxsackie virus

Assay antiviral assay

Activity

[Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=500 µM);
HHV-1 clinical strain:inhibition of virus replication in Vero cells(IC50=1500 µM);
Coxsackie virus 971 PT B2:inhibition of virus replication in HEp-2 cells(IC50=1040 µM);inhibition of virus replication in LLC-MK2 cells(IC50=540 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 1174 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00769

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C15H24N6O5

Absent amino acids ACDEFIKLMNPQRSTWY

Common amino acids G

Mass 368.39

Pl 6.74

Basic residues 1

Acidic residues 0

Hydrophobic residues 1

Net charge 1

Boman Index 126

Hydrophobicity 5

Aliphatic Index 72.5

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title New alloferon analogues: synthesis and antiviral properties.

Pubmed ID 22883213

Reference Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author Kuczer M, Majewska A, Zahorska R.

DOI 10.1111/cbdd.12020