General Information


DRAVP ID  DRAVPe00769

Peptide Name   Alloferon (10-13)

Sequence  GVHG

Sequence Length  4

UniProt ID  P83412 

Source  Synthetic construct(derived from Alloferon-1)



Activity Information


Target Organism  Herpesvirus,Coxsackie virus

Assay  antiviral assay

Activity 

  • [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=500 µM);
  • HHV-1 clinical strain:inhibition of virus replication in Vero cells(IC50=1500 µM);
  • Coxsackie virus 971 PT B2:inhibition of virus replication in HEp-2 cells(IC50=1040 µM);inhibition of virus replication in LLC-MK2 cells(IC50=540 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.22883213]No cytotoxic against Vero, Hep-2 and LLC-MK2 cells up to 1174 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00769

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C15H24N6O5

Absent amino acids  ACDEFIKLMNPQRSTWY

Common amino acids  G

Mass  368.39

Pl  6.74

Basic residues  1

Acidic residues  0

Hydrophobic residues  1

Net charge  1

Boman Index  126

Hydrophobicity  5

Aliphatic Index  72.5

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   New alloferon analogues: synthesis and antiviral properties.

Pubmed ID   22883213

Reference   Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author   Kuczer M, Majewska A, Zahorska R.

DOI   10.1111/cbdd.12020