General Information


DRAVP ID  DRAVPe00770

Peptide Name   Alloferon (1-11)

Sequence  HGVSGHGQHGV

Sequence Length  11

UniProt ID  P83412 

Source  Synthetic construct(derived from Alloferon-1)



Activity Information


Target Organism  Herpesvirus

Assay  antiviral assay

Activity 

  • [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=178 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.22883213]No cytotoxic against Vero cells up to 260 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00770

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C44H66N18O14

Absent amino acids  ACDEFIKLMNPRTWY

Common amino acids  G

Mass  1071.12

Pl  7.02

Basic residues  3

Acidic residues  0

Hydrophobic residues  2

Net charge  3

Boman Index  -1108

Hydrophobicity  -64.55

Aliphatic Index  52.73

Half Life 

  •     Mammalian:3.5 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   New alloferon analogues: synthesis and antiviral properties.

Pubmed ID   22883213

Reference   Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author   Kuczer M, Majewska A, Zahorska R.

DOI   10.1111/cbdd.12020