General Information


DRAVP ID  DRAVPe00775

Peptide Name   Alloferon [H1Y]

Sequence  YGVSGHGQHGVHG

Sequence Length  13

UniProt ID  P83412 

Source  Synthetic construct(derived from Alloferon-1)



Activity Information


Target Organism  Herpesvirus

Assay  antiviral assay

Activity 

  • [Ref.22883213]Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells(IC50=190 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.22883213]No cytotoxic against Vero cells up to 315 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00775

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C55H78N20O17

Absent amino acids  ACDEFIKLMNPRTW

Common amino acids  G

Mass  1291.35

Pl  7.02

Basic residues  3

Acidic residues  0

Hydrophobic residues  2

Net charge  3

Boman Index  -1028

Hydrophobicity  -67.69

Aliphatic Index  44.62

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:10 min
  •     E.coli:2 min

Extinction Coefficient cystines  1490

Absorbance 280nm  124.17

Polar residues  7



Literature Information


Literature 1

Title   New alloferon analogues: synthesis and antiviral properties.

Pubmed ID   22883213

Reference   Chem Biol Drug Des. 2013 Feb;81(2):302-9.

Author   Kuczer M, Majewska A, Zahorska R.

DOI   10.1111/cbdd.12020