To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00796
Peptide Name C41 [R4X](R4C)
Sequence EWDXEINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLW
Sequence Length 41
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HIV
Assay cell-cell fusion inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target envelope glycoprotein(gp41)
Mechanism The peptide have been shown to be effective inhibitors to prevent virus–host cell membrane fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification The 'X' at position 4 indicates PEG750-Cys.
Stereochemistry L
Physicochemical Information
Formula C217H323N55O74
Absent amino acids CFGMPRV
Common amino acids E
Mass 5015.62
Pl 4.04
Basic residues 3
Acidic residues 10
Hydrophobic residues 13
Net charge -7
Boman Index -9963
Hydrophobicity -106.83
Aliphatic Index 88.05
Half Life
Extinction Coefficient cystines 17990
Absorbance 280nm 449.75
Polar residues 10
Literature Information
Literature 1
Title Site-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation.
Pubmed ID 22770564
Reference Bioconjug Chem. 2012 Aug 15;23(8):1648-60.
Author Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.