General Information


DRAVP ID  DRAVPe00815

Peptide Name   IQN36

Sequence  RMKQIEDKIEEIESKQKKIENEIARIKKLISGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL

Sequence Length  66

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Other Link  DRAVPa0206

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HIV

Assay  HIV luciferase assay

Activity 

  • [Ref.11572974]HIV-1:inhibition of cell-cell fusion between 293T cells and HOS-CD4/fusion cells(IC50=0.088±0.035 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  The peptide inhibits HIV-1 entry by inhibiting the fusion between virus and cell membrane.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00815

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C345H594N102O99S

Absent amino acids  CFPY

Common amino acids  IQ

Mass  7787.19

Pl  9.77

Basic residues  13

Acidic residues  8

Hydrophobic residues  26

Net charge  5

Boman Index  -13446

Hydrophobicity  -49.24

Aliphatic Index  127.12

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  84.62

Polar residues  8



Literature Information


Literature 1

Title   Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region.

Pubmed ID   11572974

Reference   Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11187-92.

Author   Eckert DM, Kim PS.

DOI   10.1073/pnas.201392898