General Information


DRAVP ID  DRAVPe00825

Peptide Name   Dermaseptin-S1 (1-29)[K4T,T12K]

Sequence  ALWTTMLKKLGKMALHAGKAALGAAADTI

Sequence Length  29

UniProt ID  P24302 

Source  Synthetic construct(derived from Dermaseptin-S1)



Activity Information


Target Organism  HSV

Assay  antiviral assay

Activity 

  • [Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=1.3 µM).

Hemolytic Activity 

  • [Ref.20718719]human red cells:HC50>100 µM.

Cytotoxicity 

  • [Ref.20718719]Vero cells:CC50=20 µM;293TT(embryonic human culture cells):CC50=40 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00825

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C133H226N36O35S2

Absent amino acids  CEFNPQRSVY

Common amino acids  A

Mass  2953.6

Pl  10

Basic residues  5

Acidic residues  1

Hydrophobic residues  15

Net charge  4

Boman Index  1056

Hydrophobicity  52.41

Aliphatic Index  108.28

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  196.43

Polar residues  6



Literature Information


Literature 1

Title   In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID   20718719

Reference   APMIS. 2010 Sep 1;118(9):674-80.

Author   Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI   10.1111/j.1600-0463.2010.02637.x