General Information

General Information

DRAVP ID DRAVPe00825

Peptide Name Dermaseptin-S1 (1-29)[K4T,T12K]

Sequence ALWTTMLKKLGKMALHAGKAALGAAADTI

Sequence Length 29

UniProt ID P24302

Source Synthetic construct(derived from Dermaseptin-S1)

Activity Information

Target Organism HSV

Assay antiviral assay

Activity

[Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=1.3 µM).

Hemolytic Activity

[Ref.20718719]human red cells:HC50>100 µM.

Cytotoxicity

[Ref.20718719]Vero cells:CC50=20 µM;293TT(embryonic human culture cells):CC50=40 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00825

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C133H226N36O35S2

Absent amino acids CEFNPQRSVY

Common amino acids A

Mass 2953.6

Pl 10

Basic residues 5

Acidic residues 1

Hydrophobic residues 15

Net charge 4

Boman Index 1056

Hydrophobicity 52.41

Aliphatic Index 108.28

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 196.43

Polar residues 6

Literature Information

Literature 1

Title In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID 20718719

Reference APMIS. 2010 Sep 1;118(9):674-80.

Author Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI 10.1111/j.1600-0463.2010.02637.x