General Information

General Information

DRAVP ID DRAVPe00828

Peptide Name Dermaseptin-S1 (1-15)[W3H]

Sequence ALHKTMLKKLGTMAL

Sequence Length 15

UniProt ID P24302

Taxon ID None

Source Synthetic construct(derived from Dermaseptin-S1)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HSV

Assay antiviral assay

Activity

[Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=5 µM).

Hemolytic Activity

[Ref.20718719]human red cells:HC50=100 µM.

Cytotoxicity

[Ref.20718719]Vero cells:CC50>100 µM;293TT(embryonic human culture cells):CC50>100 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00828

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C74H134N20O18S2

Absent amino acids CDEFINPQRSVWY

Common amino acids L

Mass 1656.12

Pl 10.3

Basic residues 4

Acidic residues 0

Hydrophobic residues 6

Net charge 4

Boman Index 249

Hydrophobicity 39.33

Aliphatic Index 117.33

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Literature Information

Literature 1

Title In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID 20718719

Reference APMIS. 2010 Sep 1;118(9):674-80.

Author Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI 10.1111/j.1600-0463.2010.02637.x