General Information

General Information

DRAVP ID DRAVPe00829

Peptide Name K-Dermaseptin-S1 (1-15)[W31NAL]

Sequence KALXKTMLKKLGTMAL

Sequence Length 16

UniProt ID P24302

Source Synthetic construct(derived from Dermaseptin-S1)

Activity Information

Target Organism HSV

Assay antiviral assay

Activity

[Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=5 µM).

Hemolytic Activity

[Ref.20718719]human red cells:HC50=80 µM.

Cytotoxicity

[Ref.20718719]Vero cells:CC50=50 µM;293TT(embryonic human culture cells):CC50>100 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification The 'X' at position 4 indicates Nal (3-[1-naphthyl]alanine).

Stereochemistry L

Physicochemical Information

Formula C74H137N19O17S2

Absent amino acids CDEFHINPQRSVWY

Common amino acids KL

Mass 1758.48

Pl 10.48

Basic residues 4

Acidic residues 0

Hydrophobic residues 6

Net charge 4

Boman Index 160

Hydrophobicity 32.5

Aliphatic Index 110

Half Life

Mammalian:1.3 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Literature Information

Literature 1

Title In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID 20718719

Reference APMIS. 2010 Sep 1;118(9):674-80.

Author Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI 10.1111/j.1600-0463.2010.02637.x