DRAVP ID  DRAVPe00829

Peptide Name   K-Dermaseptin-S1 (1-15)[W31NAL]

Sequence  KALXKTMLKKLGTMAL

Sequence Length  16

UniProt ID  P24302 

Taxon ID  None

Source  Synthetic construct(derived from Dermaseptin-S1)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV

Assay  antiviral assay

Activity 

• [Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=5 µM).

Hemolytic Activity 

• [Ref.20718719]human red cells:HC50=80 µM.

Cytotoxicity 

• [Ref.20718719]Vero cells:CC50=50 µM;293TT(embryonic human culture cells):CC50>100 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  The 'X' at position 4 indicates Nal (3-[1-naphthyl]alanine).

Stereochemistry  L

Literature 1

Title   In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID   20718719

Reference   APMIS. 2010 Sep 1;118(9):674-80.

Author   Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI   10.1111/j.1600-0463.2010.02637.x