General Information


DRAVP ID  DRAVPe00830

Peptide Name   Dermaseptin-S1 (1-14)

Sequence  ALWKTMLKKLGTMA

Sequence Length  14

UniProt ID  P24302 

Source  Synthetic construct(derived from Dermaseptin-S1)



Activity Information


Target Organism  HSV

Assay  antiviral assay

Activity 

  • [Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=10.5 µM).

Hemolytic Activity 

  • [Ref.20718719]human red cells:HC50>100 µM.

Cytotoxicity 

  • [Ref.20718719]Vero cells:CC50=85 µM;293TT(embryonic human culture cells):CC50>100 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00830

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C73H126N18O17S2

Absent amino acids  CDEFHINPQRSVY

Common amino acids  KL

Mass  1592.03

Pl  10.3

Basic residues  3

Acidic residues  0

Hydrophobic residues  6

Net charge  3

Boman Index  456

Hydrophobicity  31.43

Aliphatic Index  97.86

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  423.08

Polar residues  3



Literature Information


Literature 1

Title   In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID   20718719

Reference   APMIS. 2010 Sep 1;118(9):674-80.

Author   Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI   10.1111/j.1600-0463.2010.02637.x