General Information

General Information

DRAVP ID DRAVPe00830

Peptide Name Dermaseptin-S1 (1-14)

Sequence ALWKTMLKKLGTMA

Sequence Length 14

UniProt ID P24302

Taxon ID None

Source Synthetic construct(derived from Dermaseptin-S1)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HSV

Assay antiviral assay

Activity

[Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=10.5 µM).

Hemolytic Activity

[Ref.20718719]human red cells:HC50>100 µM.

Cytotoxicity

[Ref.20718719]Vero cells:CC50=85 µM;293TT(embryonic human culture cells):CC50>100 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00830

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C73H126N18O17S2

Absent amino acids CDEFHINPQRSVY

Common amino acids KL

Mass 1592.03

Pl 10.3

Basic residues 3

Acidic residues 0

Hydrophobic residues 6

Net charge 3

Boman Index 456

Hydrophobicity 31.43

Aliphatic Index 97.86

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 423.08

Polar residues 3

Literature Information

Literature 1

Title In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID 20718719

Reference APMIS. 2010 Sep 1;118(9):674-80.

Author Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI 10.1111/j.1600-0463.2010.02637.x