General Information

General Information

DRAVP ID DRAVPe00830

Peptide Name Dermaseptin-S1 (1-14)

Sequence ALWKTMLKKLGTMA

Sequence Length 14

UniProt ID P24302

Source Synthetic construct(derived from Dermaseptin-S1)

Activity Information

Target Organism HSV

Assay antiviral assay

Activity

[Ref.20718719]HSV-1:inhibition of virus infection in Vero cells(IC50=10.5 µM).

Hemolytic Activity

[Ref.20718719]human red cells:HC50>100 µM.

Cytotoxicity

[Ref.20718719]Vero cells:CC50=85 µM;293TT(embryonic human culture cells):CC50>100 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00830

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C73H126N18O17S2

Absent amino acids CDEFHINPQRSVY

Common amino acids KL

Mass 1592.03

Pl 10.3

Basic residues 3

Acidic residues 0

Hydrophobic residues 6

Net charge 3

Boman Index 456

Hydrophobicity 31.43

Aliphatic Index 97.86

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 423.08

Polar residues 3

Literature Information

Literature 1

Title In vitro activity of dermaseptin S1 derivatives against genital pathogens.

Pubmed ID 20718719

Reference APMIS. 2010 Sep 1;118(9):674-80.

Author Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R.

DOI 10.1111/j.1600-0463.2010.02637.x