General Information
DRAVP ID DRAVPe00835
Peptide Name YIK-C16(625-656)
Sequence EMTWEEWEKKIEEYIKKIEEILKKSQNQQIDLGSGX
Sequence Length 36
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV
Assay HIV-1-Mediated Cell-Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism It was a fusion inhibitor and inhibits cell-cell fusion
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification The 'X' at position 36 indicates PEG4-Lys-C16(Palmitic Acid).
Stereochemistry L
Physicochemical Information
Formula C191H301N47O61S
Absent amino acids ACFHPRV
Common amino acids E
Mass 4393.18
Pl 4.73
Basic residues 6
Acidic residues 9
Hydrophobic residues 9
Net charge -3
Boman Index -8594
Hydrophobicity -119.72
Aliphatic Index 75.83
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 356.86
Polar residues 7
Literature Information
Literature 1
Title A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life.
Pubmed ID 30901967
Reference Molecules. 2019 Mar 21;24(6):1134.
Author Su S, Rasquinha G, Du L, Wang Q, Xu W, Li W, Lu L, Jiang S.