General Information

General Information

DRAVP ID DRAVPe00838

Peptide Name Magainin-1

Sequence GIGKFLHSAGKFGKAFVGEIMKS

Sequence Length 23

UniProt ID P11006

Taxon ID None

Source Xenopus laevis (African clawed frog)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HSV

Assay

Activity

[Ref.15081088]Herpes simplex virus type 1 (HSV-1):inhibition of HSV-1 infection in Vero cells(EC50=36.59 μM);
Herpes simplex virus type 2 (HSV-2):inhibition of HSV-2 infection in Vero cells(EC50=33.20 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.15081088]Vero cells:CC50>100 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00838

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C112H177N29O28S

Absent amino acids CDNPQRTWY

Common amino acids G

Mass 2409.87

Pl 10

Basic residues 5

Acidic residues 1

Hydrophobic residues 9

Net charge 4

Boman Index -206

Hydrophobicity 21.74

Aliphatic Index 72.17

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 7

Literature Information

Literature 1

Title Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.

Pubmed ID 15081088

Reference Int J Antimicrob Agents. 2004 Apr;23(4):382-9.

Author Albiol Matanic VC, Castilla V.

DOI 10.1016/j.ijantimicag.2003.07.022