General Information

General Information

DRAVP ID DRAVPe00838

Peptide Name Magainin-1

Sequence GIGKFLHSAGKFGKAFVGEIMKS

Sequence Length 23

UniProt ID P11006

Source Xenopus laevis (African clawed frog)

Activity Information

Target Organism HSV

Assay

Activity

[Ref.15081088]Herpes simplex virus type 1 (HSV-1):inhibition of HSV-1 infection in Vero cells(EC50=36.59 μM);
Herpes simplex virus type 2 (HSV-2):inhibition of HSV-2 infection in Vero cells(EC50=33.20 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.15081088]Vero cells:CC50>100 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID

Predicted Structure Download DRAVPe00838

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C112H177N29O28S

Absent amino acids CDNPQRTWY

Common amino acids G

Mass 2409.87

Pl 10

Basic residues 5

Acidic residues 1

Hydrophobic residues 9

Net charge 4

Boman Index -206

Hydrophobicity 21.74

Aliphatic Index 72.17

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 7

Literature Information

Literature 1

Title Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.

Pubmed ID 15081088

Reference Int J Antimicrob Agents. 2004 Apr;23(4):382-9.

Author Albiol Matanic VC, Castilla V.

DOI 10.1016/j.ijantimicag.2003.07.022