DRAVP ID  DRAVPe00839

Peptide Name   Magainin II

Sequence  GIGKFLHSAKKFGKAFVGEIMNS

Sequence Length  23

UniProt ID  C0HKN6 

Source  Xenopus ruwenzoriensis (Uganda clawed frog)

Target Organism  CCV,HSV

Assay 

Activity 

• [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 48 μM).
• [Ref.15081088]Herpes simplex virus type 1 (HSV-1):inhibition of HSV-1 infection in Vero cells(EC50=22.16 μM);
• Herpes simplex virus type 2 (HSV-2):inhibition of HSV-2 infection in Vero cells(EC50=19.80 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15081088]Vero cells:CC50>100 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2MAG  2LSA 

Predicted Structure Download  DRAVPe00839

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029

Literature 2

Title   Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.

Pubmed ID   15081088

Reference   Int J Antimicrob Agents. 2004 Apr;23(4):382-9.

Author   Albiol Matanic VC, Castilla V.

DOI   10.1016/j.ijantimicag.2003.07.022