DRAVP ID  DRAVPe00839

Peptide Name   Magainin II

Sequence  GIGKFLHSAKKFGKAFVGEIMNS

Sequence Length  23

UniProt ID  C0HKN6 

Taxon ID  None

Source  Xenopus ruwenzoriensis (Uganda clawed frog)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  CCV,HSV

Assay 

Activity 

• [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 48 μM).
• [Ref.15081088]Herpes simplex virus type 1 (HSV-1):inhibition of HSV-1 infection in Vero cells(EC50=22.16 μM);
• Herpes simplex virus type 2 (HSV-2):inhibition of HSV-2 infection in Vero cells(EC50=19.80 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15081088]Vero cells:CC50>100 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2MAG  2LSA 

Predicted Structure Download  DRAVPe00839

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029

Literature 2

Title   Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.

Pubmed ID   15081088

Reference   Int J Antimicrob Agents. 2004 Apr;23(4):382-9.

Author   Albiol Matanic VC, Castilla V.

DOI   10.1016/j.ijantimicag.2003.07.022