To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00854
Peptide Name 22(derived from FIV envelope glycoprotein )
Sequence KQRNRWEWRPDFKSKKVKISLPC
Sequence Length 23
UniProt ID P16090
Source Synthetic construct(derived from FIV envelope glycoprotein (gE))
Activity Information
Target Organism FIV
Assay Syncitia assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Syncytium formation
Mechanism The machanism might be peptide bound the surface of FIV permissive cells and were highly active in blocking FIV infection when administered before the virus.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00854
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C133H213N41O32S
Absent amino acids AGHMTY
Common amino acids K
Mass 2930.47
Pl 10.56
Basic residues 8
Acidic residues 2
Hydrophobic residues 6
Net charge 6
Boman Index -8422
Hydrophobicity -155.65
Aliphatic Index 46.52
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 500
Polar residues 4
Literature Information
Literature 1
Title Inhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides.
Pubmed ID 8661378
Reference Virology. 1996 Jun 15;220(2):274-84.
Author Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.