General Information


DRAVP ID  DRAVPe00854

Peptide Name   22(derived from FIV envelope glycoprotein )

Sequence  KQRNRWEWRPDFKSKKVKISLPC

Sequence Length  23

UniProt ID  P16090 

Source  Synthetic construct(derived from FIV envelope glycoprotein (gE))



Activity Information


Target Organism  FIV

Assay  Syncitia assay

Activity 

  • [Ref.8661378]Feline immunodeficiency virus (FIV):inhibition of virus replication in Crandell feline kidney (CrFK) fibroblastoid cells(6% inhibition at 16 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Syncytium formation

Mechanism  The machanism might be peptide bound the surface of FIV permissive cells and were highly active in blocking FIV infection when administered before the virus.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00854

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C133H213N41O32S

Absent amino acids  AGHMTY

Common amino acids  K

Mass  2930.47

Pl  10.56

Basic residues  8

Acidic residues  2

Hydrophobic residues  6

Net charge  6

Boman Index  -8422

Hydrophobicity  -155.65

Aliphatic Index  46.52

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  500

Polar residues  4



Literature Information


Literature 1

Title   Inhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides.

Pubmed ID   8661378

Reference   Virology. 1996 Jun 15;220(2):274-84. 

Author   Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C.

DOI   10.1006/viro.1996.0315