To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00874
Peptide Name 43(derived from FIV envelope glycoprotein )
Sequence YKPRRKRAAIHVMLALATVLSI
Sequence Length 22
UniProt ID P16090
Source Synthetic construct(derived from FIV envelope glycoprotein (gE))
Activity Information
Target Organism FIV
Assay Syncitia assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Syncytium formation
Mechanism The machanism might be peptide bound the surface of FIV permissive cells and were highly active in blocking FIV infection when administered before the virus.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00874
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C114H199N35O26S
Absent amino acids CDEFGNQW
Common amino acids A
Mass 2508.11
Pl 11.73
Basic residues 6
Acidic residues 0
Hydrophobic residues 11
Net charge 6
Boman Index -2436
Hydrophobicity 40.91
Aliphatic Index 133.18
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 70.95
Polar residues 3
Literature Information
Literature 1
Title Inhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides.
Pubmed ID 8661378
Reference Virology. 1996 Jun 15;220(2):274-84.
Author Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.