General Information


DRAVP ID  DRAVPe00949

Peptide Name   T-265

Sequence  PISLERLDVGTNLGNAIAKLEDAKELLESSDQILR

Sequence Length  35

UniProt ID  P69353 

Source  Synthetic construct(derived from measles virus(MV) fusion (F) protein)



Activity Information


Target Organism  MeV

Assay  Cytopathic effect(CPE) assay

Activity 

  • [Ref.8700906]measles virus(MV):protection of HEp2 cell from viral cytopathic effect(CPE)(EC50=3.1 μg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.8700906]No significant cytotoxic against HEp2 cells(CC50>100 μM).

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00949

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C165H282N46O57

Absent amino acids  CFHMWY

Common amino acids  L

Mass  3822.33

Pl  4.44

Basic residues  4

Acidic residues  7

Hydrophobic residues  14

Net charge  -3

Boman Index  -6538

Hydrophobicity  -21.71

Aliphatic Index  128.29

Half Life 

  •     Mammalian:>20 hour
  •     Yeast:>20 hour
  •     E.coli:?

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  8



Literature Information


Literature 1

Title   Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. 

Pubmed ID   8700906

Reference   Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91.

Author   Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr.

DOI   10.1073/pnas.93.5.2186