General Information
DRAVP ID DRAVPe00963
Peptide Name P12(derived from HCV polyprotein)
Sequence ADLEVVAATHVLVA
Sequence Length 14
UniProt ID P26662
Taxon ID None
Source Synthetic construct(derived from Hepatitis C virus(HCV) polyprotein)
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HCV
Assay NS3-6K inhibition assay(determined by Fluorescent probe)
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS3 protease
Mechanism HCV NS3 protease is essential for the processing of HCV polyprotein, this protease is a target of choice to control HCV replication. The peptide was demonstrated that can indeed block the activity of NS3 and thus inhibit HCV replication
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00963
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C63H106N16O20
Absent amino acids CFGIKMNPQRSWY
Common amino acids AV
Mass 1407.63
Pl 4.35
Basic residues 1
Acidic residues 2
Hydrophobic residues 10
Net charge -1
Boman Index 1048
Hydrophobicity 147.86
Aliphatic Index 167.14
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Literature Information
Literature 1
Title Peptide inhibitors of hepatitis C virus NS3 protease.
Pubmed ID 14694985
Reference Antivir Chem Chemother. 2003 Sep;14(5):225-33.
Author Portal-Núñez S, González-Navarro CJ, García-Delgado M, Vizmanos JL, Lasarte JJ, Borrás-Cuesta F.