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General Information
DRAVP ID DRAVPe01023
Peptide Name P104(derived from HCV polyprotein)
Sequence KKKKVVAATYVGV
Sequence Length 13
UniProt ID P26662
Source Synthetic construct(derived from Hepatitis C virus(HCV) polyprotein)
Activity Information
Target Organism HCV
Assay NS3-6K inhibition assay(determined by Fluorescent probe)
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS3 protease
Mechanism HCV NS3 protease is essential for the processing of HCV polyprotein, this protease is a target of choice to control HCV replication. The peptide was demonstrated that can indeed block the activity of NS3 and thus inhibit HCV replication
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01023
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C65H115N17O16
Absent amino acids CDEFHILMNPQRSW
Common amino acids KV
Mass 1390.73
Pl 10.18
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -419
Hydrophobicity 18.46
Aliphatic Index 104.62
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 124.17
Polar residues 3
Literature Information
Literature 1
Title Peptide inhibitors of hepatitis C virus NS3 protease.
Pubmed ID 14694985
Reference Antivir Chem Chemother. 2003 Sep;14(5):225-33.
Author Portal-Núñez S, González-Navarro CJ, García-Delgado M, Vizmanos JL, Lasarte JJ, Borrás-Cuesta F.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.