To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01119
Peptide Name HCV(1496-1500)
Sequence RGIYR
Sequence Length 5
UniProt ID P26663
Source Synthetic construct(derived from HCV NS3 helicase protein)
Activity Information
Target Organism HCV,WNV,JEV
Assay Helicase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NTPase/helicase
Mechanism The intact enzymatic properties of NS3 are necessary for the virus propagation,which possesses numerous enzymatic activities including RNA stimulated nucleoside triphosphatase (NTPase) and RNA helicase activities. The peptides inhibited the NTPase/helicase by a direct interaction with the enzyme highly probably by a competitive mechanism.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01119
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C29H49N11O7
Absent amino acids ACDEFHKLMNPQSTVW
Common amino acids R
Mass 663.78
Pl 10.84
Basic residues 2
Acidic residues 0
Hydrophobic residues 1
Net charge 2
Boman Index -2412
Hydrophobicity -124
Aliphatic Index 78
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 372.5
Polar residues 2
Literature Information
Literature 1
Title Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI).
Pubmed ID 18479669
Reference Biochem Pharmacol. 2008 Jul 1;76(1):28-38.
Author Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.