General Information


DRAVP ID  DRAVPe01136

Peptide Name   gB122Y5A

Sequence  GHRRAFTFGGGYVYF

Sequence Length  15

UniProt ID  P06437 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))



Activity Information


Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay)

Activity 

  • [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=119.2 ± 26.6 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01136

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C83H111N23O19

Absent amino acids  CDEIKLMNPQSW

Common amino acids  G

Mass  1734.94

Pl  9.99

Basic residues  3

Acidic residues  0

Hydrophobic residues  5

Net charge  3

Boman Index  -1880

Hydrophobicity  -18

Aliphatic Index  26

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  2980

Absorbance 280nm  212.86

Polar residues  7



Literature Information


Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08