General Information


DRAVP ID  DRAVPe01137

Peptide Name   gB122F6A

Sequence  GHRRYATFGGGYVYF

Sequence Length  15

UniProt ID  P06437 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))



Activity Information


Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay)

Activity 

  • [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=67.6 ± 8.1 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01137

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C83H111N23O20

Absent amino acids  CDEIKLMNPQSW

Common amino acids  G

Mass  1750.94

Pl  9.7

Basic residues  3

Acidic residues  0

Hydrophobic residues  4

Net charge  3

Boman Index  -2192

Hydrophobicity  -45.33

Aliphatic Index  26

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  4470

Absorbance 280nm  319.29

Polar residues  8



Literature Information


Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08