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General Information
DRAVP ID DRAVPe01177
Peptide Name C18-c03
Sequence RAVWRHSVATPSHSV
Sequence Length 15
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism H3N2,H1N1
Assay Plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target sialylgalactose
Mechanism The peptide has affinity for glycoconjugates on the cell surface. And its binding to the cell resulted in the significant inhibition of influenza virus infections.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01177
Linear/Cyclic Linear
N-terminal Modification Alkylated(C18)
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C74H116N26O20
Absent amino acids CDEFGIKLMNQY
Common amino acids SV
Mass 1689.9
Pl 12
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -3386
Hydrophobicity -32
Aliphatic Index 71.33
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 392.86
Polar residues 4
Literature Information
Literature 1
Title Inhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library.
Pubmed ID 19558186
Reference J Med Chem. 2009 Jul 23;52(14):4247-56.
Author Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.