General Information


DRAVP ID  DRAVPe01177

Peptide Name   C18-c03

Sequence  RAVWRHSVATPSHSV

Sequence Length  15

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  H3N2,H1N1

Assay  Plaque assay

Activity 

  • [Ref.19558186]H1N1(A/PR/8/34):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=6.5 μM);
  • H3N2(A/Aichi/2/68):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=68 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  sialylgalactose

Mechanism  The peptide has affinity for glycoconjugates on the cell surface. And its binding to the cell resulted in the significant inhibition of influenza virus infections.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01177

Linear/Cyclic  Linear

N-terminal Modification  Alkylated(C18)

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C74H116N26O20

Absent amino acids  CDEFGIKLMNQY

Common amino acids  SV

Mass  1689.9

Pl  12

Basic residues  4

Acidic residues  0

Hydrophobic residues  6

Net charge  4

Boman Index  -3386

Hydrophobicity  -32

Aliphatic Index  71.33

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  392.86

Polar residues  4



Literature Information


Literature 1

Title   Inhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. 

Pubmed ID   19558186

Reference   J Med Chem. 2009 Jul 23;52(14):4247-56.

Author   Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T.

DOI   10.1021/jm801570y