DRAVP ID  DRAVPe01185

Peptide Name   EB

Sequence  RRKKAAVALLPAVLLALLAP

Sequence Length  20

UniProt ID  P08620 

Source  Synthetic construct(derived from FGF-4 signal sequence)

Other Link  DRAVPa1689

Target Organism  Influenza virus

Assay  Hemagglutinin assay

Activity 

• [Ref.21220525]Influenza virus:inhibit hemagglutination of 64 HA units of virus of MDCK cells(95 ± 2% inhibition at 10 μM,EC50=3.2 ± 0.0 μM).

Hemolytic Activity 

• [Ref.21220525]Did not lyse red blood cells up to 30 μM.

Cytotoxicity 

• [Ref.21220525]A549 cells:CD50=83.5 ± 22.0 μM;
• MDCK cells:CD50=85.5 ± 1.3 μM.

Binding Target  Not found

Mechanism  The peptide inhibits influenza virus replication by preventing attachment to cells.

PDB ID  None

Predicted Structure Download  DRAVPe01185

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of the minimal active sequence of an anti-influenza virus peptide. 

Pubmed ID   21220525

Reference    Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3.

Author   Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. 

DOI   10.1128/AAC.01428-10