DRAVP ID  DRAVPe01185

Peptide Name   EB

Sequence  RRKKAAVALLPAVLLALLAP

Sequence Length  20

UniProt ID  P08620 

Taxon ID  None

Source  Synthetic construct(derived from FGF-4 signal sequence)

Other Link  DRAVPa1689

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  Influenza virus

Assay  Hemagglutinin assay

Activity 

• [Ref.21220525]Influenza virus:inhibit hemagglutination of 64 HA units of virus of MDCK cells(95 ± 2% inhibition at 10 μM,EC50=3.2 ± 0.0 μM).

Hemolytic Activity 

• [Ref.21220525]Did not lyse red blood cells up to 30 μM.

Cytotoxicity 

• [Ref.21220525]A549 cells:CD50=83.5 ± 22.0 μM;
• MDCK cells:CD50=85.5 ± 1.3 μM.

Binding Target  Not found

Mechanism  The peptide inhibits influenza virus replication by preventing attachment to cells.

PDB ID  None

Predicted Structure Download  DRAVPe01185

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of the minimal active sequence of an anti-influenza virus peptide. 

Pubmed ID   21220525

Reference    Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3.

Author   Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. 

DOI   10.1128/AAC.01428-10