General Information


DRAVP ID  DRAVPe01186

Peptide Name   A2

Sequence  RRKKAAVALLPAVLLALLA

Sequence Length  19

UniProt ID  P08620 

Source  Synthetic construct(derived from FGF-4 signal sequence)

Other Link  DRAVPa1690



Activity Information


Target Organism  Influenza virus

Assay  Hemagglutinin assay

Activity 

  • [Ref.21220525]Influenza virus:inhibit hemagglutination of 64 HA units of virus of MDCK cells(94 ± 2% inhibition at 10 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The peptide inhibits influenza virus replication by preventing attachment to cells.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01186

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C93H171N27O20

Absent amino acids  CDEFGHIMNQSTWY

Common amino acids  AL

Mass  1987.55

Pl  12.02

Basic residues  4

Acidic residues  0

Hydrophobic residues  14

Net charge  4

Boman Index  752

Hydrophobicity  124.21

Aliphatic Index  185.26

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Identification of the minimal active sequence of an anti-influenza virus peptide. 

Pubmed ID   21220525

Reference    Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3.

Author   Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. 

DOI   10.1128/AAC.01428-10