General Information


DRAVP ID  DRAVPe01201

Peptide Name   B8NP

Sequence  RRKKALLAVLLALLA

Sequence Length  15

UniProt ID  P08620 

Source  Synthetic construct(derived from FGF-4 signal sequence)



Activity Information


Target Organism  Influenza virus

Assay  Hemagglutinin assay

Activity 

  • [Ref.21220525]Influenza virus:inhibit hemagglutination of 64 HA units of virus of MDCK cells(EC50=0.4 ± 0.2 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The peptide inhibits influenza virus replication by preventing attachment to cells.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01201

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C77H145N23O16

Absent amino acids  CDEFGHIMNPQSTWY

Common amino acids  L

Mass  1649.14

Pl  12.02

Basic residues  4

Acidic residues  0

Hydrophobic residues  11

Net charge  4

Boman Index  -14

Hydrophobicity  116

Aliphatic Index  202

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Identification of the minimal active sequence of an anti-influenza virus peptide. 

Pubmed ID   21220525

Reference    Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3.

Author   Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. 

DOI   10.1128/AAC.01428-10