General Information

General Information

DRAVP ID DRAVPe01203

Peptide Name B10NP

Sequence RRKKLAVLLALLA

Sequence Length 13

UniProt ID P08620

Source Synthetic construct(derived from FGF-4 signal sequence)

Other Link DRAVPa1723

Activity Information

Target Organism Influenza virus

Assay Hemagglutinin assay

Activity

[Ref.21220525]Influenza virus:inhibit hemagglutination of 64 HA units of virus of MDCK cells(EC50=3.5 ± 2.6 μM).

Hemolytic Activity

[Ref.21220525]Did not lyse human red blood cells up to 30 μM.

Cytotoxicity

[Ref.21220525]A549 cells:CD50=120.0 ± 28.0 μM;
MDCK cells:CD50=90.0 ± 16.3 μM.

Binding Target Not found

Mechanism The peptide inhibits influenza virus replication by preventing attachment to cells.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01203

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C68H129N21O14

Absent amino acids CDEFGHIMNPQSTWY

Common amino acids L

Mass 1464.9

Pl 12.02

Basic residues 4

Acidic residues 0

Hydrophobic residues 9

Net charge 4

Boman Index -687

Hydrophobicity 90.77

Aliphatic Index 195.38

Half Life

Mammalian:1 hour
Yeast:2 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Identification of the minimal active sequence of an anti-influenza virus peptide.

Pubmed ID 21220525

Reference Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3.

Author Jones JC, Settles EW, Brandt CR, Schultz-Cherry S.

DOI 10.1128/AAC.01428-10