General Information


DRAVP ID  DRAVPe01208

Peptide Name   RJ6

Sequence  AKKAAKKAKKAAKKAKKWAKK

Sequence Length  21

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV

Assay  Plaque reduction assay,ELISA

Activity 

  • [Ref.15498607]herpes simplex virus 1(HSV-1):inhibition of HSV-1 infection in MRC-5 cells(IC50=47.3 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.15498607]human fibroblasts(MRC-5 cells):CC50>433 μM.

Binding Target  Not found

Mechanism  The peptide was able to inhibit the entry of HSV-1 into the host cell, probably by blocking heparan sulfate(HS) at the cell surface.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01208

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C107H196N34O22

Absent amino acids  CDEFGHILMNPQRSTVY

Common amino acids  K

Mass  2310.95

Pl  11.04

Basic residues  12

Acidic residues  0

Hydrophobic residues  9

Net charge  12

Boman Index  -4979

Hydrophobicity  -158.57

Aliphatic Index  38.1

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  275

Polar residues  0



Literature Information


Literature 1

Title   A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus.

Pubmed ID   15498607

Reference   Antiviral Res. 2004 Nov;64(2):119-26.

Author   Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. 

DOI   10.1016/j.antiviral.2004.08.003