General Information

General Information

DRAVP ID DRAVPe01213

Peptide Name Peptide 59(FIV ectodomain 767-786)

Sequence QLQKWEDWVRWIGNIPQYLKG

Sequence Length 21

UniProt ID P16090

Source Synthetic construct(derived from the Membrane-Proximal Ectodomain of Feline Immunodeficiency Virus)

Activity Information

Target Organism FIV

Assay enzyme-linked immunosorbent assay(ELISA)

Activity

[Ref.12610147]FIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells(IC50=0.03 µg/ml);
FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells(IC50=0.01 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.12610147]No detectable cytotoxicity on MBM cell viability and proliferation.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01213

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C126H185N33O31

Absent amino acids ACFHMST

Common amino acids QW

Mass 2658.06

Pl 8.5

Basic residues 3

Acidic residues 2

Hydrophobic residues 8

Net charge 1

Boman Index -3236

Hydrophobicity -90

Aliphatic Index 88.1

Half Life

Mammalian:0.8 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 17990

Absorbance 280nm 899.5

Polar residues 4

Literature Information

Literature 1

Title Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.

Pubmed ID 12610147

Reference J Virol. 2003 Mar;77(6):3724-33.

Author Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M.

DOI 10.1128/jvi.77.6.3724-3733.2003