General Information

General Information

DRAVP ID DRAVPe01215

Peptide Name C12b(FIV ectodomain 770-781)

Sequence WEDWVRWIGNIP

Sequence Length 12

UniProt ID P16090

Source Synthetic construct(derived from the Membrane-Proximal Ectodomain of Feline Immunodeficiency Virus)

Activity Information

Target Organism FIV

Assay enzyme-linked immunosorbent assay(ELISA)

Activity

[Ref.12610147]FIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells(IC50=0.04 µg/ml);
FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells(IC50=0.09 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01215

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C76H103N19O18

Absent amino acids ACFHKLMQSTY

Common amino acids W

Mass 1570.77

Pl 4.37

Basic residues 1

Acidic residues 2

Hydrophobic residues 6

Net charge -1

Boman Index -1528

Hydrophobicity -54.17

Aliphatic Index 89.17

Half Life

Mammalian:2.8 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 16500

Absorbance 280nm 1500

Polar residues 2

Literature Information

Literature 1

Title Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.

Pubmed ID 12610147

Reference J Virol. 2003 Mar;77(6):3724-33.

Author Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M.

DOI 10.1128/jvi.77.6.3724-3733.2003