General Information


DRAVP ID  DRAVPe01229

Peptide Name   C8W->A776

Sequence  WEDWVRAI

Sequence Length  8

UniProt ID  P16090 

Source  Synthetic construct(derived from the Membrane-Proximal Ectodomain of Feline Immunodeficiency Virus)



Activity Information


Target Organism  FIV

Assay  enzyme-linked immunosorbent assay(ELISA)

Activity 

  • [Ref.12610147]FIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells(IC50>50 µg/ml);
  • FIV-GL8(Feline immunodeficiency virus GL8):inhibition of virus replication in MBM cells(IC50>50);
  • FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells(IC50>50 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.12610153]No detectable cytotoxicity on MBM cell viability and proliferation.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01229

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C51H71N13O13

Absent amino acids  CFGHKLMNPQSTY

Common amino acids  W

Mass  1074.2

Pl  4.37

Basic residues  1

Acidic residues  2

Hydrophobic residues  5

Net charge  -1

Boman Index  -1502

Hydrophobicity  -35

Aliphatic Index  97.5

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  1571.43

Polar residues  0



Literature Information


Literature 1

Title   Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.

Pubmed ID   12610147

Reference   J Virol. 2003 Mar;77(6):3724-33.

Author   Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M.

DOI   10.1128/jvi.77.6.3724-3733.2003