General Information


DRAVP ID  DRAVPe01243

Peptide Name   77-95[87A]

Sequence  TDVILMCFSIASPDSLENI

Sequence Length  19

UniProt ID  P08134 

Source  Synthetic construct(derived from RhoA protein)



Activity Information


Target Organism  RSV

Assay  viral antigen reduction assay

Activity 

  • [Ref.14576104]respiratory syncytial virus(RSV):inhibition of RSV replication in HEp-2 cells(IC50=4.36 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01243

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C90H146N20O31S2

Absent amino acids  GHKQRWY

Common amino acids  IS

Mass  2068.38

Pl  3.49

Basic residues  0

Acidic residues  3

Hydrophobic residues  8

Net charge  -3

Boman Index  -660

Hydrophobicity  82.11

Aliphatic Index  123.16

Half Life 

  •     Mammalian:7.2 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Antiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimers.

Pubmed ID   14576104

Reference   Antimicrob Agents Chemother. 2003 Nov;47(11):3470-7.

Author   Budge PJ, Lebowitz J, Graham BS. 

DOI   10.1128/AAC.47.11.3470-3477.2003