General Information


DRAVP ID  DRAVPe01264

Peptide Name   80-89

Sequence  ILMCFSIDSP

Sequence Length  10

UniProt ID  P08134 

Source  Synthetic construct(derived from RhoA protein)



Activity Information


Target Organism  RSV

Assay  viral antigen reduction assay

Activity 

  • [Ref.14576104]respiratory syncytial virus(RSV):inhibition of RSV replication in HEp-2 cells(IC50=35.77 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01264

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C50H80N10O15S2

Absent amino acids  AEGHKNQRTVWY

Common amino acids  IS

Mass  1125.36

Pl  3.8

Basic residues  0

Acidic residues  1

Hydrophobic residues  4

Net charge  -1

Boman Index  585

Hydrophobicity  133

Aliphatic Index  117

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Antiviral activity of RhoA-derived peptides against respiratory syncytial virus is dependent on formation of peptide dimers.

Pubmed ID   14576104

Reference   Antimicrob Agents Chemother. 2003 Nov;47(11):3470-7.

Author   Budge PJ, Lebowitz J, Graham BS. 

DOI   10.1128/AAC.47.11.3470-3477.2003