General Information

General Information

DRAVP ID DRAVPe01276

Peptide Name 7-P9

Sequence HRILMRARQMMT

Sequence Length 12

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism PRRSV

Assay MTT assay

Activity

[Ref.22743126]Porcine reproductive and respiratory syndrome virus(PRRSV):inhibition of PRRSV replication in MARC-145 cells(IC50=150.1405 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.22743126]MARC-145 cells:CC50>500 μM.

Binding Target PRRSV polymerase

Mechanism PRRSV polymerase is an RNA-dependent RNA polymerase and is an enzyme specific to viruses, RNA-dependent RNA polymerase is one of the most important proteins for intracellular replication of viruses.The peptide could exert antiviral activity by inhibiting polymerase.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01276

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C63H114N24O15S3

Absent amino acids CDEFGKNPSVWY

Common amino acids MR

Mass 1543.93

Pl 12.3

Basic residues 4

Acidic residues 0

Hydrophobic residues 3

Net charge 4

Boman Index -3883

Hydrophobicity -42.5

Aliphatic Index 73.33

Half Life

Mammalian:3.5 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro.

Pubmed ID 22743126

Reference Virology. 2012 Oct 10;432(1):73-80.

Author Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P.

DOI 10.1016/j.virol.2012.05.010