General Information


DRAVP ID  DRAVPe01279

Peptide Name   10-P9

Sequence  HRILMRIRQAMT

Sequence Length  12

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  PRRSV

Assay  MTT assay

Activity 

  • [Ref.22743126]Porcine reproductive and respiratory syndrome virus(PRRSV):inhibition of PRRSV replication in MARC-145 cells(IC50=57.98146 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.22743126]MARC-145 cells:CC50>500 μM.

Binding Target  PRRSV polymerase

Mechanism  PRRSV polymerase is an RNA-dependent RNA polymerase and is an enzyme specific to viruses, RNA-dependent RNA polymerase is one of the most important proteins for intracellular replication of viruses.The peptide could exert antiviral activity by inhibiting polymerase.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01279

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C64H116N24O15S2

Absent amino acids  CDEFGKNPSVWY

Common amino acids  R

Mass  1525.9

Pl  12.3

Basic residues  4

Acidic residues  0

Hydrophobic residues  4

Net charge  4

Boman Index  -3626

Hydrophobicity  -20.83

Aliphatic Index  105.83

Half Life 

  •     Mammalian:3.5 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro.

Pubmed ID   22743126

Reference   Virology. 2012 Oct 10;432(1):73-80.

Author   Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P. 

DOI   10.1016/j.virol.2012.05.010