DRAVP ID  DRAVPe01284

Peptide Name   c-p9

Sequence  LMRIR

Sequence Length  5

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  PRRSV

Assay  MTT assay

Activity 

• [Ref.22743126]Porcine reproductive and respiratory syndrome virus(PRRSV):inhibition of PRRSV replication in MARC-145 cells(IC50=716.4193 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.22743126]MARC-145 cells:CC50>500 μM.

Binding Target  PRRSV polymerase

Mechanism  PRRSV polymerase is an RNA-dependent RNA polymerase and is an enzyme specific to viruses, RNA-dependent RNA polymerase is one of the most important proteins for intracellular replication of viruses.The peptide could exert antiviral activity by inhibiting polymerase.

PDB ID  None

Predicted Structure Download  DRAVPe01284

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro.

Pubmed ID   22743126

Reference   Virology. 2012 Oct 10;432(1):73-80.

Author   Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P. 

DOI   10.1016/j.virol.2012.05.010