General Information


DRAVP ID  DRAVPe01319

Peptide Name   CL58.2

Sequence  LLGFILAFLGWIGAIVST

Sequence Length  18

UniProt ID  O95832 

Source  Synthetic construct(derived from human claudin-1)



Activity Information


Target Organism  HCV

Assay  Pseudoviral particle infection assay

Activity 

  • [Ref.22378192]Hepatitis C virus(HCV):inhibition of viral-entry in Huh7.5.1 cells(IC50=4.3 ± 0.3 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  membrane protein

Mechanism  The peptide inhibits virus entry in a postbinding step.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01319

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C95H147N19O21

Absent amino acids  CDEHKMNPQRY

Common amino acids  L

Mass  1891.33

Pl  5.52

Basic residues  0

Acidic residues  0

Hydrophobic residues  13

Net charge  0

Boman Index  4724

Hydrophobicity  213.89

Aliphatic Index  178.89

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  323.53

Polar residues  5



Literature Information


Literature 1

Title   A human claudin-1-derived peptide inhibits hepatitis C virus entry.

Pubmed ID   22378192

Reference   Hepatology. 2012 Aug;56(2):507-17. 

Author   Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. 

DOI   10.1002/hep.25685