General Information


DRAVP ID  DRAVPe01327

Peptide Name   CL58-2

Sequence  MANAGLQLLGFILAFL

Sequence Length  16

UniProt ID  O95832 

Source  Synthetic construct(derived from human claudin-1)



Activity Information


Target Organism  HCV

Assay  Pseudoviral particle infection assay

Activity 

  • [Ref.22378192]Hepatitis C virus(HCV):inhibition of viral-entry in Huh7.5.1 cells(IC50=7.6± 0.9 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  membrane protein

Mechanism  The peptide inhibits virus entry in a postbinding step.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01327

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C81H130N18O19S

Absent amino acids  CDEHKPRSTVWY

Common amino acids  L

Mass  1692.09

Pl  5.28

Basic residues  0

Acidic residues  0

Hydrophobic residues  11

Net charge  0

Boman Index  3296

Hydrophobicity  178.75

Aliphatic Index  165

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   A human claudin-1-derived peptide inhibits hepatitis C virus entry.

Pubmed ID   22378192

Reference   Hepatology. 2012 Aug;56(2):507-25. 

Author   Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. 

DOI   10.1002/hep.25685