To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01330
Peptide Name CL58+6
Sequence MANAGLQLLGFILAFLGWIGAIVS
Sequence Length 24
UniProt ID O95832
Source Synthetic construct(derived from human claudin-1)
Activity Information
Target Organism HCV
Assay Pseudoviral particle infection assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane protein
Mechanism The peptide inhibits virus entry in a postbinding step.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01330
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C119H187N27O28S
Absent amino acids CDEHKPRTY
Common amino acids L
Mass 2476.02
Pl 5.28
Basic residues 0
Acidic residues 0
Hydrophobic residues 16
Net charge 0
Boman Index 4946
Hydrophobicity 171.25
Aliphatic Index 158.75
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 239.13
Polar residues 6
Literature Information
Literature 1
Title A human claudin-1-derived peptide inhibits hepatitis C virus entry.
Pubmed ID 22378192
Reference Hepatology. 2012 Aug;56(2):507-28.
Author Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.