General Information


DRAVP ID  DRAVPe01331

Peptide Name   CL58.d

Sequence  managlqllgfilaflgw

Sequence Length  18

UniProt ID  No entry found

Source 



Activity Information


Target Organism  HCV

Assay  Pseudoviral particle infection assay

Activity 

  • [Ref.22378192]Hepatitis C virus(HCV):inhibition of viral-entry in Huh7.5.1 cells(IC50=1.8 ± 0.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  membrane protein

Mechanism  The peptide inhibits virus entry in a postbinding step.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  D



Physicochemical Information


Formula  H-34O-17

Absent amino acids  ACDEFGHIKLMNPQRSTVWY

Common amino acids  ACDEFGHIKLMNPQRSTVWY

Mass  1935.36

Pl  5.28

Basic residues  0

Acidic residues  0

Hydrophobic residues  0

Net charge  0

Boman Index  0

Hydrophobicity  0

Aliphatic Index  0

Half Life 

  •     Mammalian:
  •     Yeast:
  •     E.coli:

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   A human claudin-1-derived peptide inhibits hepatitis C virus entry.

Pubmed ID   22378192

Reference   Hepatology. 2012 Aug;56(2):507-29. 

Author   Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. 

DOI   10.1002/hep.25685