General Information


DRAVP ID  DRAVPe01355

Peptide Name   H2-(10-15)

Sequence  AVVNDL

Sequence Length  6

UniProt ID  P10224 

Source  Synthetic construct(derived from HSV ribonucleotide reductase subunit 2)



Activity Information


Target Organism  HSV

Assay  Ribonucleotide reductase assay

Activity 

  • [Ref.3040743]Herpes simplex virus type 1:inhibition of HSV-1 ribonucleotide reductase activity(IC50=190 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  ribonucleotide reductase

Mechanism  The peptide inhibits the activity of ribonucleotide rductase.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01355

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C27H47N7O10

Absent amino acids  CEFGHIKMPQRSTWY

Common amino acids  V

Mass  629.71

Pl  3.8

Basic residues  0

Acidic residues  1

Hydrophobic residues  4

Net charge  -1

Boman Index  -55

Hydrophobicity  116.67

Aliphatic Index  178.33

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Structure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase.

Pubmed ID   3040743

Reference   J Biol Chem. 1987 Sep 15;262(26):12413-6.

Author   Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P.

DOI   Not available