General Information


DRAVP ID  DRAVPe01363

Peptide Name   [Tyr8]H2-(8-15)

Sequence  YGAVVNDL

Sequence Length  8

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV

Assay  Ribonucleotide reductase assay

Activity 

  • [Ref.3040743]Herpes simplex virus type 1:inhibition of HSV-1 ribonucleotide reductase activity(IC50=330 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  ribonucleotide reductase

Mechanism  The peptide inhibits the activity of ribonucleotide rductase.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01363

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C38H59N9O13

Absent amino acids  CEFHIKMPQRSTW

Common amino acids  V

Mass  849.94

Pl  3.8

Basic residues  0

Acidic residues  1

Hydrophobic residues  4

Net charge  -1

Boman Index  25

Hydrophobicity  66.25

Aliphatic Index  133.75

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:10 min
  •     E.coli:2 min

Extinction Coefficient cystines  1490

Absorbance 280nm  212.86

Polar residues  3



Literature Information


Literature 1

Title   Structure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase.

Pubmed ID   3040743

Reference   J Biol Chem. 1987 Sep 15;262(26):12413-6.

Author   Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P.

DOI   Not available