General Information


DRAVP ID  DRAVPe01371

Peptide Name   [D-Ala8]H2-(7-15)

Sequence  YaGAVVNDL

Sequence Length  9

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV

Assay  Ribonucleotide reductase assay

Activity 

  • [Ref.3040743]Herpes simplex virus type 1:inhibition of HSV-1 ribonucleotide reductase activity(IC50=200 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  ribonucleotide reductase

Mechanism  The peptide inhibits the activity of ribonucleotide rductase.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  Mixed(D-Ala2)



Physicochemical Information


Formula  C38H57N9O12

Absent amino acids  CEFHIKMPQRSTW

Common amino acids  V

Mass  921.02

Pl  3.8

Basic residues  0

Acidic residues  1

Hydrophobic residues  4

Net charge  -1

Boman Index  25

Hydrophobicity  58.89

Aliphatic Index  118.89

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:10 min
  •     E.coli:2 min

Extinction Coefficient cystines  1490

Absorbance 280nm  186.25

Polar residues  3



Literature Information


Literature 1

Title   Structure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase.

Pubmed ID   3040743

Reference   J Biol Chem. 1987 Sep 15;262(26):12413-6.

Author   Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P.

DOI   Not available