General Information

General Information

DRAVP ID DRAVPe01378

Peptide Name DC1

Sequence FAVAVKAVAVKAVAVKAVKKAVKKVKKAVKKAVKKKK

Sequence Length 37

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism FIV

Assay reverse transcriptase (RT) assay

Activity

[Ref.12208971]Feline immunodeficiency virus(FIV-Petaluma):inhibition of reverse transcriptase activity in CrFK cells(IC50=0.75 μM);
Feline immunodeficiency virus(FIV-Black):inhibition of reverse transcriptase activity in CrFK cells(IC50=0.78 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.12208971]CrFK cell:TC50=9.20 μM.

Binding Target Not found

Mechanism The peptide may facilitate interference with viral assembly or release and reduce the number of infectious progeny virions.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01378

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C184H340N52O38

Absent amino acids CDEGHILMNPQRSTWY

Common amino acids K

Mass 3889.05

Pl 11.15

Basic residues 15

Acidic residues 0

Hydrophobic residues 22

Net charge 15

Boman Index -1773

Hydrophobicity 22.97

Aliphatic Index 113.24

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro.

Pubmed ID 12208971

Reference J Virol. 2002 Oct;76(19):9952-61.

Author Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA.

DOI 10.1128/jvi.76.19.9952-9961.2002