General Information

General Information

DRAVP ID DRAVPe01379

Peptide Name D1D6

Sequence FLAAARIAKRVAKKARKLAKRAARKRK

Sequence Length 27

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism FIV

Assay reverse transcriptase (RT) assay

Activity

[Ref.12208971]Feline immunodeficiency virus(FIV-Petaluma):inhibition of reverse transcriptase activity in CrFK cells(IC50=0.94 μM);
Feline immunodeficiency virus(FIV-Black):inhibition of reverse transcriptase activity in CrFK cells(IC50=1.47 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.12208971]CrFK cell:TC50=8.93 μM.

Binding Target Not found

Mechanism The peptide may facilitate interference with viral assembly or release and reduce the number of infectious progeny virions.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01379

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C137H254N52O28

Absent amino acids CDEGHMNPQSTWY

Common amino acids A

Mass 3077.86

Pl 12.71

Basic residues 13

Acidic residues 0

Hydrophobic residues 14

Net charge 13

Boman Index -9030

Hydrophobicity -70.37

Aliphatic Index 87.41

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro.

Pubmed ID 12208971

Reference J Virol. 2002 Oct;76(19):9952-61.

Author Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA.

DOI 10.1128/jvi.76.19.9952-9961.2002