General Information


DRAVP ID  DRAVPe01387

Peptide Name   D5C

Sequence  KRKRAVKRVGRRLKKKLARKIARLGVAF

Sequence Length  28

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  FIV

Assay  reverse transcriptase (RT) assay

Activity 

  • [Ref.12208971]Feline immunodeficiency virus(FIV-Petaluma):inhibition of reverse transcriptase activity in CrFK cells(IC50=7.82 μM);
  • Feline immunodeficiency virus(FIV-Black):inhibition of reverse transcriptase activity in CrFK cells(IC50=6.84 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.12208971]CrFK cell:TC50=7.48 μM.

Binding Target  Not found

Mechanism  The peptide may facilitate interference with viral assembly or release and reduce the number of infectious progeny virions.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01387

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C148H276N56O29

Absent amino acids  CDEHMNPQSTWY

Common amino acids  KR

Mass  3304.18

Pl  12.78

Basic residues  14

Acidic residues  0

Hydrophobic residues  12

Net charge  14

Boman Index  -9939

Hydrophobicity  -75.36

Aliphatic Index  101.07

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. 

Pubmed ID   12208971

Reference   J Virol. 2002 Oct;76(19):9952-61.

Author   Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA.

DOI   10.1128/jvi.76.19.9952-9961.2002