General Information


DRAVP ID  DRAVPe01445

Peptide Name   G158-177

Sequence  KPNNDFHFEVFNFVPBSIBG

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  RSV

Assay  NMR

Activity 

  • [Ref.11487583]Respiratory syncytial virus(RSV):inhibition of the cytopathic effect of RSV in HEp-2 cells(IC50=50 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01445

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  The 'B' at position 16,19 are S-acetamidomethyl cysteine.

Stereochemistry  L



Physicochemical Information


Formula  C100H134N24O25

Absent amino acids  ACLMQRTWY

Common amino acids  F

Mass  2337.65

Pl  5.32

Basic residues  2

Acidic residues  2

Hydrophobic residues  7

Net charge  0

Boman Index  -2320

Hydrophobicity  -24.5

Aliphatic Index  48.5

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein.

Pubmed ID   11487583

Reference   J Biol Chem. 2001 Oct 19;276(42):38988-94.

Author   Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. 

DOI   10.1074/jbc.M106288200